E. coli on an LP - The Power of CRISPR-Cas Mediated Genome Editi
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Visual Explanation of the CRISPR-cas System

Escherichia coli

Magnification: 417:1

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This hand-colored scanning-electron-micrograph (SEM) shows cells of the human gut bacterium Escherichia coli (E. coli) on a phonograph record of Ludwig van Beethoven’s Moonlight Sonata (Sonata No 14 in C).

E. coli has been engineered to express the molecular components of another bacterium’s CRISPR-Cas system – an adaptive bacterial immune system that enables it to write a permanent record of the RNAs within the cell into its own genome where it is safely stored. Much like the Beethoven’s composition, this record is preserved over many generations. Scientist can retrieve it at any time to reveal the mysteries of the bacterium’s transcriptional history.