Clonal evolution versus cancer stem cell theory
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Clonal Evolution vs. Cancer Stem Cells – I

Homo sapiens

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In cancer research two fundamentally different mechanisms explaining tumor progression currently split the positions: Clonal evolution versus cancer stem cells. To develop more effective cancer therapies it will be critical to determine which theory holds true. If most cells can proliferatie and metastasize, then virtually all cells must be eradicated to cure the disease, whereas the specific elimination of cancer stem cells would be sufficient, if the theory of clonal evolution is a myth…